Version 5.4
| Mus musculus Protein: Tlr12 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-190100.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Tlr12 | ||||||
| Protein Name | toll-like receptor 12 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000074381 | ||||||
| InnateDB Gene | IDBG-190098 (Tlr12) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system. {ECO:0000250, ECO:0000269PubMed:15001781}. | ||||||
| Subcellular Localization | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Macrophages, liver, kidney and bladder epithelial cells. {ECO:0000269PubMed:15001781}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:3045221 | ||||||
| InterPro |
IPR000157
Toll/interleukin-1 receptor homology (TIR) domain IPR001611 Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype |
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| PFAM |
PF01582
PF13676 PF00560 PF13504 PF13855 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00255
SM00369 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q6QNU9 | ||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | Q3UPN5 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 384059 | ||||||
| UniGene | Mm.331901 | ||||||
| RefSeq | NP_991392 | ||||||
| MGI ID | |||||||
| MGI Symbol | Tlr12 | ||||||
| OMIM | |||||||
| CCDS | CCDS18673 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AK137624 AK143385 AY510705 AY531552 BC131921 | ||||||
| GenPept | AAI31922 AAS37673 AAS83531 BAE23434 BAE25360 | ||||||