InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim62

Summary

InnateDB Protein

IDBP-190193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim62

Protein Name

tripartite motif-containing 62

Synonyms

6330414G21Rik; AI450348;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039121

InnateDB Gene

IDBG-190191 (Trim62)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0046596	regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902186	regulation of viral release from host cell

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914775

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt