Version 5.4
Mus musculus Protein: Cirh1a
Summary
InnateDB Protein IDBP-190219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cirh1a
Protein Name cirrhosis, autosomal recessive 1A (human)
Synonyms Cirhin; Naic; Teg-292; Tex292;
Species Mus musculus
Ensembl Protein ENSMUSP00000048377
InnateDB Gene IDBG-190215 (Cirh1a)
Protein Structure
UniProt Annotation
Function May be a transcriptional regulator. Acts as a positive regulator of HIVEP1. Ribosome biogenesis factor involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in liver. {ECO:0000269PubMed:12417987, ECO:0000269PubMed:8703127}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030490 maturation of SSU-rRNA
Cellular Component
GO:0005730 nucleolus
GO:0034455 t-UTP complex
Protein Structure and Domains
PDB ID MGI:1096573
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R2N2
PhosphoSite PhosphoSite-Q8R2N2
TrEMBL
UniProt Splice Variant
Entrez Gene 21771
UniGene Mm.402485
RefSeq NP_035704
MGI ID
MGI Symbol Cirh1a
OMIM
CCDS CCDS52664
HPRD
IMGT
EMBL AK173318 BC018262 BC027399 BC068113 X80433 X80434
GenPept AAH18262 AAH27399 AAH68113 BAD32596 CAA56628 CAA56629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca