InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sntb2

Summary

InnateDB Protein

IDBP-190294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sntb2

Protein Name

syntrophin, basic 2

Synonyms

Snt2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037324

InnateDB Gene

IDBG-190292 (Sntb2)

Protein Structure

UniProt Annotation

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:9214383}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:9214383}; Peripheral membrane protein {ECO:0000269PubMed:9214383}. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9214383}. Note=Membrane-associated. In insulinoma cell line, it is enriched in secretory granules (By similarity). In muscle, it is exclusively localized at the neuromuscular junction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at high levels in the testis. {ECO:0000269PubMed:9214383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0044822	poly(A) RNA binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0030054	cell junction
GO:0030658	transport vesicle membrane
GO:0043234	protein complex
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome