InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dyrk4

Summary

InnateDB Protein

IDBP-190363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dyrk4

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Synonyms

AW049118; Dyrk4a; Dyrk4b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077606

InnateDB Gene

IDBG-190359 (Dyrk4)

Protein Structure

UniProt Annotation

Function

Possible non-essential role in spermiogenesis. {ECO:0000269PubMed:17292540}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:Q9NR20}.

Disease Associations

Tissue Specificity

Highly expressed in testes. {ECO:0000269PubMed:17292540}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468

protein phosphorylation

Cellular Component

GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1330292

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt