InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcl2

Summary

InnateDB Protein

IDBP-190436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcl2

Protein Name

phospholipase C-like 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046584

InnateDB Gene

IDBG-190434 (Plcl2)

Protein Structure

UniProt Annotation

Function

May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000269PubMed:10581172}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10581172}. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with a strong expression in skeletal muscle. {ECO:0000269PubMed:10581172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0050811	GABA receptor binding

Biological Process

GO:0002322	B cell proliferation involved in immune response
GO:0002337	B-1a B cell differentiation
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0033135	regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0050859	negative regulation of B cell receptor signaling pathway
GO:1900122	positive regulation of receptor binding

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1352756

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF00169
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00148
SM00149
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt