Version 5.4
Mus musculus Protein: Fcamr
Summary
InnateDB Protein IDBP-190445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcamr
Protein Name Fc receptor, IgA, IgM, high affinity
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000027670
InnateDB Gene IDBG-190443 (Fcamr)
Protein Structure
UniProt Annotation
Function Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. {ECO:0000269PubMed:11062505}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11062505}; Single-pass type I membrane protein {ECO:0000269PubMed:11062505}.
Disease Associations
Tissue Specificity Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B-cells and macrophages but not granulocytes, T-cells or NK cells (at protein level). {ECO:0000269PubMed:11062505, ECO:0000269PubMed:12527391}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001791 IgM binding
GO:0004888 transmembrane signaling receptor activity
GO:0019862 IgA binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1927803
InterPro IPR003599 Immunoglobulin subtype
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2TB54
PhosphoSite PhosphoSite-Q2TB54
TrEMBL
UniProt Splice Variant
Entrez Gene 64435
UniGene Mm.31821
RefSeq NP_659209
MGI ID
MGI Symbol Fcamr
OMIM
CCDS CCDS15259
HPRD
IMGT
EMBL AB048834 AB071978 BC110549 BC110550
GenPept AAI10550 AAI10551 BAB17312 BAB71750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca