InnateDB Protein
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IDBP-190513.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fndc5
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Protein Name
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fibronectin type III domain containing 5
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099660
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InnateDB Gene
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IDBG-190511 (Fndc5)
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Protein Structure
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Function |
Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. {ECO:0000269PubMed:22237023}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Secreted. Note=Imported in peroxisomes through the PEX5 receptor pathway.Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise.
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Disease Associations |
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Tissue Specificity |
In adult, it is highly expressed in skeletal muscle, heart and brain. {ECO:0000269PubMed:12112469, ECO:0000269PubMed:12384288}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0014850
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response to muscle activity
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GO:0090336
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positive regulation of brown fat cell differentiation
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Cellular Component |
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PDB ID |
MGI:1917614
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K4Z2
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PhosphoSite |
PhosphoSite-Q8K4Z2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
384061
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UniGene |
Mm.457725
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RefSeq |
NP_081678
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MGI ID |
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MGI Symbol |
Fndc5
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OMIM |
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CCDS |
CCDS18683
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HPRD |
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IMGT |
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EMBL |
AJ401376
AK005096
AL606977
BC109183
BC109184
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GenPept |
AAI09184
AAI09185
BAB23815
CAC82194
CAM19716
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