Version 5.4
Mus musculus Protein: Faim3
Summary
InnateDB Protein IDBP-190539.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Faim3
Protein Name Fas apoptotic inhibitory molecule 3
Synonyms 1810037B05Rik; FcmuR; Toso;
Species Mus musculus
Ensembl Protein ENSMUSP00000048303
InnateDB Gene IDBG-190537 (Faim3)
Protein Structure
UniProt Annotation
Function May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002376 immune system process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1916419
InterPro IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1KXC4
PhosphoSite PhosphoSite-A1KXC4
TrEMBL Q3U0V8
UniProt Splice Variant
Entrez Gene 69169
UniGene Mm.46042
RefSeq NP_081252
MGI ID
MGI Symbol Faim3
OMIM
CCDS CCDS15261
HPRD
IMGT
EMBL AK007714 AK155943 AK156523 AY227385 AY227386 AY227387 AY227388 AY227389 AY227390 AY227391 AY227392 AY227393 BC116674 BC118505
GenPept AAI16675 AAI18506 AAP51723 AAP51724 AAP51725 AAP51726 AAP51727 AAP51728 AAP51729 AAP51730 AAP51731 BAB25207 BAE33514 BAE33743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca