InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tph2

Summary

InnateDB Protein

IDBP-190578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tph2

Protein Name

tryptophan hydroxylase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006949

InnateDB Gene

IDBG-190576 (Tph2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0006587	serotonin biosynthetic process from tryptophan
GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0014823	response to activity
GO:0031667	response to nutrient levels
GO:0042427	serotonin biosynthetic process
GO:0043627	response to estrogen
GO:0051384	response to glucocorticoid
GO:0051592	response to calcium ion
GO:0055114	oxidation-reduction process
GO:0071285	cellular response to lithium ion

Cellular Component

GO:0043005

neuron projection

Protein Structure and Domains

PDB ID

MGI:2651811

InterPro

IPR002912 ACT domain
IPR005963 Tryptophan 5-monooxygenase
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal

PFAM

PF01842
PF00351

PRINTS

PR00372

PIRSF

PIRSF000336

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt