Version 5.4
Mus musculus Protein: Tbc1d15
Summary
InnateDB Protein IDBP-190631.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbc1d15
Protein Name TBC1 domain family, member 15
Synonyms 4432405K22Rik; AU022358; AU023730; AW557774; Ly6dl; Rab7-GAP;
Species Mus musculus
Ensembl Protein ENSMUSP00000020339
InnateDB Gene IDBG-190629 (Tbc1d15)
Protein Structure
UniProt Annotation
Function Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6. {ECO:0000269PubMed:16055087, ECO:0000269PubMed:20363736}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16055087}.
Disease Associations
Tissue Specificity Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle. {ECO:0000269PubMed:16055087}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1913937
InterPro IPR000195 Rab-GTPase-TBC domain
IPR021935 Domain of unknown function DUF3548
PFAM PF00566
PF12068
PRINTS
PIRSF
SMART SM00164
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CXF4
PhosphoSite PhosphoSite-Q9CXF4
TrEMBL Q9CRG4
UniProt Splice Variant
Entrez Gene 66687
UniGene Mm.490491
RefSeq NP_079982
MGI ID
MGI Symbol Tbc1d15
OMIM
CCDS CCDS24176
HPRD
IMGT
EMBL AK010704 AK014477 AK078875 AK147085
GenPept BAB27132 BAB29380 BAC37435 BAE27665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca