InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem88

Summary

InnateDB Protein

IDBP-190674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem88

Protein Name

transmembrane protein 88

Synonyms

2600017H02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055528

InnateDB Gene

IDBG-190672 (Tmem88)

Protein Structure

UniProt Annotation

Function

Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0008150	biological_process
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005575	cellular_component
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1914270

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D0N8

PhosphoSite

PhosphoSite-Q9D0N8

TrEMBL

UniProt Splice Variant

Entrez Gene

67020

UniGene

Mm.390406

RefSeq

NP_080191

MGI ID

MGI Symbol

Tmem88

OMIM

CCDS

CCDS24894

HPRD

IMGT

EMBL

AK011240 AK045149 AK161789 AL596125 BC100316 BC120912

GenPept

AAI00317 AAI20913 BAB27488 BAC32239 BAE36575 CAI35995