InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Efcab4b

Summary

InnateDB Protein

IDBP-190724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efcab4b

Protein Name

EF-hand calcium binding domain 4B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071494

InnateDB Gene

IDBG-190722 (Efcab4b)

Protein Structure

UniProt Annotation

Function

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0002115	store-operated calcium entry
GO:0002376	immune system process
GO:0032237	activation of store-operated calcium channel activity
GO:0051928	positive regulation of calcium ion transport