InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpyd

Summary

InnateDB Protein

IDBP-190736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpyd

Protein Name

dihydropyrimidine dehydrogenase

Synonyms

AI315208; DPD; E330028L06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039429

InnateDB Gene

IDBG-190734 (Dpyd)

Protein Structure

UniProt Annotation

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017150	tRNA dihydrouridine synthase activity
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006145	purine nucleobase catabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006210	thymine catabolic process
GO:0006212	uracil catabolic process
GO:0006214	thymidine catabolic process
GO:0006222	UMP biosynthetic process
GO:0008033	tRNA processing
GO:0019483	beta-alanine biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:2139667

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR001269 tRNA-dihydrouridine synthase
IPR005720 Dihydroorotate dehydrogenase domain
IPR009051 Alpha-helical ferredoxin
IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF01207
PF01180
PF07992

PRINTS

PR00469
PR00368

PIRSF

PIRSF006621
PIRSF000164

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt