InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prmt8

Summary

InnateDB Protein

IDBP-190758.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prmt8

Protein Name

protein arginine N-methyltransferase 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032500

InnateDB Gene

IDBG-190756 (Prmt8)

Protein Structure

UniProt Annotation

Function

Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain-specific. Only expressed in neurons, especially in the somatosensory and limbic systems, and a part of motor system. Highly expressed in all of the regions related to general somatosensory system. Expressed in most of the relay nuclei intervening the special somatosensory system, such as the auditory, visual and vestibular systems. Also present in forebrain limbic areas and thalamic nuclei relevant to limbic areas and in areas related to the motor system, such as the caudate putamen, Purkinje cells, inferior olivary nucleus and cerebellar nuclei. {ECO:0000269PubMed:17512914}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016740	transferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034969	histone arginine methylation
GO:0043985	histone H4-R3 methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:3043083

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF06325
PF08241
PF05185

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PAK3

PhosphoSite