InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbbp4

Summary

InnateDB Protein

IDBP-190816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbbp4

Protein Name

retinoblastoma binding protein 4

Synonyms

mRbAp48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099658

InnateDB Gene

IDBG-190814 (Rbbp4)

Protein Structure

UniProt Annotation

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Higher levels in brain, thymus, lung, spleen, kidney, testis, and ovary/uterus; lower levels in heart, liver, and muscle. {ECO:0000269PubMed:7503932}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 131 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	131 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0031492	nucleosomal DNA binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0031497	chromatin assembly
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016581	NuRD complex
GO:0016589	NURF complex
GO:0033186	CAF-1 complex
GO:0035098	ESC/E(Z) complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1194912

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR022052 Histone-binding protein RBBP4, N-terminal

PFAM

PF00400
PF12265

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt