InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddb2

Summary

InnateDB Protein

IDBP-190923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddb2

Protein Name

damage specific DNA binding protein 2

Synonyms

2610043A19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028696

InnateDB Gene

IDBG-190919 (Ddb2)

Protein Structure

UniProt Annotation

Function

Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. {ECO:0000269PubMed:12107171}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17635991}. Note=Accumulates at sites of DNA damage following UV irradiation.

Disease Associations

Tissue Specificity

Expressed in bone marrow, liver, lung, muscle, pancreas and spleen. {ECO:0000269PubMed:15558025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006290	pyrimidine dimer repair
GO:0009411	response to UV
GO:0035518	histone H2A monoubiquitination
GO:0051865	protein autoubiquitination
GO:0070914	UV-damage excision repair