Version 5.4
Mus musculus Protein: Efnb3
Summary
InnateDB Protein IDBP-190947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efnb3
Protein Name ephrin B3
Synonyms EFL-6; ELF-3; Elk-L3; Epl8; LERK-8; NLERK-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000004036
InnateDB Gene IDBG-190945 (Efnb3)
Protein Structure
UniProt Annotation
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269PubMed:10704386}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed on lateral floor plate cells, specifically on commissural axon segments that have passed through the floor plate. Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046875 ephrin receptor binding
Biological Process
GO:0007411 axon guidance
GO:0007628 adult walking behavior
GO:0016198 axon choice point recognition
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:109196
InterPro IPR001799 Ephrin
IPR008972 Cupredoxin
PFAM PF00812
PRINTS PR01347
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35393
PhosphoSite PhosphoSite-O35393
TrEMBL Q543Q7
UniProt Splice Variant
Entrez Gene 13643
UniGene Mm.249637
RefSeq NP_031937
MGI ID 3D12
MGI Symbol Efnb3
OMIM
CCDS CCDS24896
HPRD
IMGT
EMBL AF025288 AK048305 BC052001 BC058617 CH466601
GenPept AAC53537 AAH52001 AAH58617 BAC33299 EDL10502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca