InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tssk3

Summary

InnateDB Protein

IDBP-191019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tssk3

Protein Name

testis-specific serine kinase 3

Synonyms

1700014N07Rik; 4930594I21Rik; Stk22c; Stk22d; Tsk-3; Tssk-3; Tssk3b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000421

InnateDB Gene

IDBG-191017 (Tssk3)

Protein Structure

UniProt Annotation

Function

May be involved in a signaling pathway during male germ cell development or mature sperm function.

Subcellular Localization

Disease Associations

Tissue Specificity

Developmentally expressed in testicular germ cells. In adult testis, expression was detected in round and condensing spermatids, but not in meiotic pachytene spermatocytes. Not expressed in brain, ovary, kidney, liver or early embryonic cells. {ECO:0000269PubMed:10781952}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0035556	intracellular signal transduction
GO:0048240	sperm capacitation

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:1929914

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt