Version 5.4
Mus musculus Protein: Mphosph10
Summary
InnateDB Protein IDBP-191081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mphosph10
Protein Name M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Synonyms 2810453H10Rik; 5730405D16Rik; AI326008;
Species Mus musculus
Ensembl Protein ENSMUSP00000032735
InnateDB Gene IDBG-191079 (Mphosph10)
Protein Structure
UniProt Annotation
Function Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:1915223
InterPro IPR007151 Mpp10 protein
IPR012173 U3 small nucleolar ribonucleoprotein complex, subunit Mpp10p
PFAM PF04006
PRINTS
PIRSF PIRSF017300
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q810V0
PhosphoSite PhosphoSite-Q810V0
TrEMBL Q8K0Z2
UniProt Splice Variant
Entrez Gene 67973
UniGene Mm.398423
RefSeq NP_080759
MGI ID
MGI Symbol Mphosph10
OMIM
CCDS CCDS21333
HPRD
IMGT
EMBL AC129199 BC029198 BC049270
GenPept AAH29198 AAH49270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca