Version 5.4
Mus musculus Protein: Plscr2
Summary
InnateDB Protein IDBP-191137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plscr2
Protein Name phospholipid scramblase 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034932
InnateDB Gene IDBG-191135 (Plscr2)
Protein Structure
UniProt Annotation
Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in erythrocyte membranes, blood platelets, blood leukocytes, T- and B-lymphocytes, vascular endothelium, spleen, thymus, prostate, testis, uterus, intestine and colon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0046872 metal ion binding
Biological Process
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1270860
InterPro IPR005552 Scramblase
PFAM PF03803
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DCW2
PhosphoSite PhosphoSite-Q9DCW2
TrEMBL D3Z7J3
UniProt Splice Variant
Entrez Gene 18828
UniGene Mm.417517
RefSeq
MGI ID
MGI Symbol Plscr2
OMIM
CCDS CCDS23405
HPRD
IMGT
EMBL AC111125 AF015790 AK002410 BC002012 BC011299 CH466560
GenPept AAC40053 AAH02012 AAH11299 BAB22079 EDL20918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca