Version 5.4
Mus musculus Protein: Shbg
Summary
InnateDB Protein IDBP-191183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shbg
Protein Name sex hormone binding globulin
Synonyms ABP;
Species Mus musculus
Ensembl Protein ENSMUSP00000005334
InnateDB Gene IDBG-191181 (Shbg)
Protein Structure
UniProt Annotation
Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005496 steroid binding
GO:0005515 protein binding
Biological Process
GO:0007285 primary spermatocyte growth
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:98295
InterPro IPR001791 Laminin G domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00054
PF02210
PRINTS
PIRSF
SMART SM00210
SM00282
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97497
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 20415
UniGene Mm.1431
RefSeq NP_035497
MGI ID
MGI Symbol Shbg
OMIM
CCDS CCDS24899
HPRD
IMGT
EMBL BC120785 BC120787 U85644
GenPept AAB42088 AAI20786 AAI20788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca