Version 5.4
Mus musculus Protein: Plscr4
Summary
InnateDB Protein IDBP-191206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plscr4
Protein Name phospholipid scramblase 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034941
InnateDB Gene IDBG-191204 (Plscr4)
Protein Structure
UniProt Annotation
Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042609 CD4 receptor binding
Biological Process
GO:0008150 biological_process
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2143267
InterPro IPR005552 Scramblase
PFAM PF03803
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58196
PhosphoSite PhosphoSite-
TrEMBL Q8BW59
UniProt Splice Variant
Entrez Gene 235527
UniGene Mm.55289
RefSeq NP_848826
MGI ID
MGI Symbol Plscr4
OMIM
CCDS CCDS23407
HPRD
IMGT
EMBL AK035919 AK054258 AK082330 AK141580 AK165919 BC052067
GenPept AAH52067 BAC29242 BAC35707 BAC38468 BAE24748 BAE38460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca