InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprb

Summary

InnateDB Protein

IDBP-191211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprb

Protein Name

protein tyrosine phosphatase, receptor type, B

Synonyms

3230402H02Rik; C130094E24; Ptpz; Rptpb; VE-PTP; Veptp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089805

InnateDB Gene

IDBG-191207 (Ptprb)

Protein Structure

UniProt Annotation

Function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. {ECO:0000269PubMed:10557082, ECO:0000269PubMed:12234928, ECO:0000269PubMed:16514057, ECO:0000269PubMed:17360632, ECO:0000269PubMed:19015309, ECO:0000269PubMed:19451274}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expression is very high in the vasculature of lung, spleen, and kidney, as well as in the heart valves, and is also present in the endothelium of arterioles and venules. Also expressed in tumor vasculature. {ECO:0000269PubMed:10557082, ECO:0000269PubMed:16514057, ECO:0000269PubMed:17360632}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0001525	angiogenesis
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:97809

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt