InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnmb4

Summary

InnateDB Protein

IDBP-191269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnmb4

Protein Name

potassium large conductance calcium-activated channel, subfamily M, beta member 4

Synonyms

1700058G18Rik; 2900045G12Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065384

InnateDB Gene

IDBG-191267 (Kcnmb4)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0015269	calcium-activated potassium channel activity

Biological Process

GO:0001508	action potential
GO:0005513	detection of calcium ion
GO:0006813	potassium ion transport
GO:0019228	neuronal action potential
GO:0071805	potassium ion transmembrane transport