InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sez6l

Summary

InnateDB Protein

IDBP-191291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sez6l

Protein Name

seizure related 6 homolog like

Synonyms

Acig1; AI843918; AIG1; AW539724; BSRP-B; mKIAA0927;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074847

InnateDB Gene

IDBG-191289 (Sez6l)

Protein Structure

UniProt Annotation

Function

Candidate tumor suppressor gene. May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305PubMed:16814779}; Single-pass type I membrane protein {ECO:0000305PubMed:16814779}. Endoplasmic reticulum membrane {ECO:0000269PubMed:16814779}; Single-pass type I membrane protein {ECO:0000269PubMed:16814779}. Note=In cerebellar predominantly localized to the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Expressed exclusively in the brain, predomimantly in neurons. Wide expression in the gray matter of the brain with high levels in the olfactory bulb, anterior olfactory nuclei, hippocampal formation and cerebellar cortex. Detected diffusely and weakly in the white matter, such as the corpus callosum and cerebellar medulla. In the cerebellar cortex, intensely expressed in Purkinje cells and granule cells. Detected also in interneurons in the molecular layer. {ECO:0000269PubMed:16814779}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008344	adult locomotory behavior
GO:0021680	cerebellar Purkinje cell layer development
GO:0060074	synapse maturation
GO:0090036	regulation of protein kinase C signaling

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body