Mus musculus Protein: Sez6l | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-191293.7 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Sez6l | ||||||||||
Protein Name | seizure related 6 homolog like | ||||||||||
Synonyms | Acig1; AI843918; AIG1; AW539724; BSRP-B; mKIAA0927; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000078454 | ||||||||||
InnateDB Gene | IDBG-191289 (Sez6l) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Candidate tumor suppressor gene. May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}. | ||||||||||
Subcellular Localization | Cell membrane {ECO:0000305PubMed:16814779}; Single-pass type I membrane protein {ECO:0000305PubMed:16814779}. Endoplasmic reticulum membrane {ECO:0000269PubMed:16814779}; Single-pass type I membrane protein {ECO:0000269PubMed:16814779}. Note=In cerebellar predominantly localized to the endoplasmic reticulum. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Expressed exclusively in the brain, predomimantly in neurons. Wide expression in the gray matter of the brain with high levels in the olfactory bulb, anterior olfactory nuclei, hippocampal formation and cerebellar cortex. Detected diffusely and weakly in the white matter, such as the corpus callosum and cerebellar medulla. In the cerebellar cortex, intensely expressed in Purkinje cells and granule cells. Detected also in interneurons in the molecular layer. {ECO:0000269PubMed:16814779}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1935121 | ||||||||||
InterPro |
IPR000436
Sushi/SCR/CCP IPR000859 CUB domain |
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PFAM |
PF00084
PF00431 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00032
SM00042 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q6P1D5 | ||||||||||
PhosphoSite | PhosphoSite- | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 56747 | ||||||||||
UniGene | Mm.414751 | ||||||||||
RefSeq | NP_001240845 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Sez6l | ||||||||||
OMIM | |||||||||||
CCDS | CCDS57373 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AB206790 AK083229 BC056471 BC065117 BC065129 BC099839 DQ167195 | ||||||||||
GenPept | AAH56471 AAH65117 AAH65129 AAH99839 AAZ99451 BAC38818 BAE44443 | ||||||||||