Version 5.4
Mus musculus Protein: Ctse
Summary
InnateDB Protein IDBP-191350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctse
Protein Name cathepsin E
Synonyms A430072O03Rik; C920004C08Rik; CatE; CE;
Species Mus musculus
Ensembl Protein ENSMUSP00000073072
InnateDB Gene IDBG-191348 (Ctse)
Protein Structure
UniProt Annotation
Function May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269PubMed:11719510, ECO:0000269PubMed:1601038}.
Subcellular Localization Endosome {ECO:0000269PubMed:1601038}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Disease Associations
Tissue Specificity Expressed abundantly in the stomach, Clara cells and alveolar macrophages of the lung, brain microglia, spleen and activated B-lymphocytes. Not expressed in resting B- lymphocytes. {ECO:0000269PubMed:11322887, ECO:0000269Ref.3}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0016540 protein autoprocessing
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005768 endosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:107361
InterPro IPR001461 Aspartic peptidase
IPR012848 Aspartic peptidase, N-terminal
IPR021109 Aspartic peptidase domain
PFAM PF00026
PF07966
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70269
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 13034
UniGene
RefSeq NP_031825
MGI ID
MGI Symbol Ctse
OMIM
CCDS CCDS15271
HPRD
IMGT
EMBL AJ009840 AJ009841 AJ009842 AJ009843 AJ009844 AJ009845 AJ009846 AJ009847 AJ009848 AK143581 AK145875 AK157907 AK165271 BC005432 CH466520 CT010252 X97399 Y10928
GenPept AAH05432 BAE25449 BAE26716 BAE34257 BAE38113 CAA08880 CAA66056 CAA71859 CAJ18460 EDL39705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca