InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chst2

Summary

InnateDB Protein

IDBP-191363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chst2

Protein Name

carbohydrate sulfotransferase 2

Synonyms

AI428561; AW121776; C130041E03Rik; Chts2; GlcNAc6ST; Gn6st; GST-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040775

InnateDB Gene

IDBG-191361 (Chst2)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269PubMed:15175329, ECO:0000269PubMed:9712885}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

In brain, it is expressed in pyramidal cells in the CA3 subregion of the hippocampus, cerebellar nucleus and Purkinje cells. {ECO:0000269PubMed:9712885, ECO:0000269PubMed:9722682}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006790	sulfur compound metabolic process
GO:0006954	inflammatory response