Version 5.4
| Mus musculus Protein: Stap2 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-191372.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Stap2 | ||||||
| Protein Name | signal transducing adaptor family member 2 | ||||||
| Synonyms | AW049765; STAP-2; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000038130 | ||||||
| InnateDB Gene | IDBG-191370 (Stap2) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000250, ECO:0000269PubMed:12540842}. | ||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:12540842}. Membrane {ECO:0000269PubMed:12540842}; Peripheral membrane protein {ECO:0000269PubMed:12540842}. Note=The translocation to the membranes occurs in response to EGF when the protein is overexpressed in fibroblastic cells. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Widely expressed. {ECO:0000269PubMed:12540842}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:2147039 | ||||||
| InterPro |
IPR000980
SH2 domain IPR001849 Pleckstrin homology domain |
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| PFAM |
PF00017
PF14633 PF00169 |
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| PRINTS |
PR00401
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| PIRSF | |||||||
| SMART |
SM00252
SM00233 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q8R0L1 | ||||||
| PhosphoSite | PhosphoSite-Q8R0L1 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 106766 | ||||||
| UniGene | Mm.438003 | ||||||
| RefSeq | NP_666046 | ||||||
| MGI ID | |||||||
| MGI Symbol | Stap2 | ||||||
| OMIM | |||||||
| CCDS | CCDS28889 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AK050131 AK050172 BC026642 | ||||||
| GenPept | AAH26642 BAC34083 BAC34107 | ||||||