InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccdc28b

Summary

InnateDB Protein

IDBP-191403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccdc28b

Protein Name

coiled coil domain containing 28B

Synonyms

1110002E08Rik; 1810010N17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030586

InnateDB Gene

IDBG-191401 (Ccdc28b)

Protein Structure

UniProt Annotation

Function

Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. {ECO:0000269PubMed:23727834}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=It localizes near centrosomes and basal bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the retina, pericardium and limb epithelium. {ECO:0000269PubMed:16327777}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0042384

cilium assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

MGI:1913514

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CEG5

PhosphoSite

PhosphoSite-Q8CEG5

TrEMBL

A2AE01

UniProt Splice Variant

Entrez Gene

66264

UniGene

RefSeq

NP_079731

MGI ID

MGI Symbol

Ccdc28b

OMIM

CCDS

CCDS18700

HPRD

IMGT

EMBL

AK028262 AK158016 AL671759 BC028873

GenPept

AAH28873 BAC25848 BAE34319 CAM15491