InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOLLIP

Summary

InnateDB Protein

IDBP-19142.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOLLIP

Protein Name

toll interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000314733

InnateDB Gene

IDBG-19140 (TOLLIP)

Protein Structure

UniProt Annotation

Function

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). {ECO:0000269PubMed:11751856, ECO:0000269PubMed:25042851}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	101 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005150	interleukin-1, Type I receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0035325	Toll-like receptor binding

Biological Process

GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0016310	phosphorylation
GO:0030855	epithelial cell differentiation
GO:0033235	positive regulation of protein sumoylation
GO:0035556	intracellular signal transduction
GO:0036010	protein localization to endosome
GO:0045087	innate immune response (InnateDB)
GO:0045321	leukocyte activation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016604	nuclear body
GO:0045092	interleukin-18 receptor complex
GO:0045323	interleukin-1 receptor complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome