Version 5.4
Mus musculus Protein: Sh3gl1
Summary
InnateDB Protein IDBP-191457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3gl1
Protein Name SH3-domain GRB2-like 1
Synonyms C77078; EEN; Sh3d2b; SH3P8;
Species Mus musculus
Ensembl Protein ENSMUSP00000003268
InnateDB Gene IDBG-191455 (Sh3gl1)
Protein Structure
UniProt Annotation
Function Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Associated with postsynaptic endosomes in hippocampal neurons. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0019902 phosphatase binding
GO:0042802 identical protein binding
GO:0051020 GTPase binding
Biological Process
GO:0006897 endocytosis
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0031901 early endosome membrane
GO:0042995 cell projection
Protein Structure and Domains
PDB ID MGI:700010
InterPro IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
IPR018859 BAR domain-containing family
PFAM PF00018
PF14604
PF03114
PF07653
PF10455
PRINTS PR00452
PIRSF
SMART SM00326
SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62419
PhosphoSite PhosphoSite-Q62419
TrEMBL Q3TRJ7
UniProt Splice Variant
Entrez Gene 20405
UniGene Mm.1773
RefSeq NP_038692
MGI ID
MGI Symbol Sh3gl1
OMIM
CCDS CCDS28891
HPRD
IMGT
EMBL AK162715 BC138602 BC138603 CH466559 U58885
GenPept AAC71775 AAI38603 AAI38604 BAE37032 EDL23706 EDL23707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca