Mus musculus Protein: Kpna6
Summary
InnateDB Protein IDBP-191502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kpna6
Protein Name karyopherin (importin) alpha 6
Synonyms IPOA7; Kpna5; NPI-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000099650
InnateDB Gene IDBG-191500 (Kpna6)
Protein Structure
UniProt Annotation
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Only slightly detected in Ehrlich ascites tumor cells, thymus and skeletal muscle, clearly detected in kidney, spleen, liver, heart, and lung. High expression in testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006606 protein import into nucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1100836
InterPro IPR000225 Armadillo
IPR000357 HEAT
IPR002652 Importin-alpha, importin-beta-binding domain
IPR016024 Armadillo-type fold
PFAM PF00514
PF02985
PF01749
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35345
PhosphoSite PhosphoSite-O35345
TrEMBL Q8BH30
UniProt Splice Variant
Entrez Gene 16650
UniGene Mm.418605
RefSeq NP_032494
MGI ID
MGI Symbol Kpna6
OMIM
CCDS CCDS18701
HPRD
IMGT
EMBL AF020773 AK007053 AK046371 AK084212 AK154882 AL671759 BC004833 CH466552 CT010260
GenPept AAC53373 AAH04833 BAB24841 BAC32694 BAC39138 BAE32900 CAJ18468 EDL30166