InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcolce2

Summary

InnateDB Protein

IDBP-191513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcolce2

Protein Name

procollagen C-endopeptidase enhancer 2

Synonyms

2400001O18Rik; Pcpe2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015498

InnateDB Gene

IDBG-191511 (Pcolce2)

Protein Structure

UniProt Annotation

Function

Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0016504	peptidase activator activity

Biological Process

GO:0010952

positive regulation of peptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1923727

InterPro

IPR000859 CUB domain
IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type

PFAM

PF00431
PF01759

PRINTS

PIRSF

SMART

SM00042
SM00643

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R4W6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

76477

UniGene

Mm.46016

RefSeq

NP_083896

MGI ID

MGI Symbol

Pcolce2

OMIM

CCDS

CCDS23410

HPRD

IMGT

EMBL

AF352788 AK010249 AK132395 BC051174

GenPept

AAH51174 AAL83947 BAB26794 BAE21144