InnateDB Protein
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IDBP-191575.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Khdrbs1
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Protein Name
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KH domain containing, RNA binding, signal transduction associated 1
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Synonyms
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p62; p68; Sam68;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000066516
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InnateDB Gene
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IDBG-191571 (Khdrbs1)
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Protein Structure
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Function |
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)- containing RNA species. {ECO:0000269PubMed:12496368, ECO:0000269PubMed:7512695, ECO:0000269PubMed:9315629}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12496368}. Membrane {ECO:0000269PubMed:12496368}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 130 interaction(s) predicted by orthology.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
0
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Protein-RNA |
2
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
130 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:893579
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InterPro |
IPR004087
K Homology domain
IPR004088
K Homology domain, type 1
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PFAM |
PF00013
PF13014
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PRINTS |
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PIRSF |
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SMART |
SM00322
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TIGRFAMs |
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Modification |
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SwissProt |
Q60749
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PhosphoSite |
PhosphoSite-Q60749
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20218
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UniGene |
Mm.8256
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RefSeq |
NP_035447
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MGI ID |
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MGI Symbol |
Khdrbs1
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OMIM |
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CCDS |
CCDS18703
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HPRD |
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IMGT |
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EMBL |
AK050520
AK152084
AL669834
BC002051
CU210913
U17046
U17961
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GenPept |
AAA64997
AAA86693
AAH02051
BAC34303
BAE30934
CAM13766
CAQ51789
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