Version 5.4
Mus musculus Protein: Klrb1b
Summary
InnateDB Protein IDBP-191582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klrb1b
Protein Name killer cell lectin-like receptor subfamily B member 1B
Synonyms Klrb1d; Ly55b; Ly55d; NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1d;
Species Mus musculus
Ensembl Protein ENSMUSP00000032472
InnateDB Gene IDBG-256726 (Klrb1b)
Protein Structure
UniProt Annotation
Function Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells. {ECO:0000269PubMed:12858173, ECO:0000269PubMed:14990792}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in NK cells and a subset of T-cells. {ECO:0000269PubMed:9390275}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:107539
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99JB4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 80782
UniGene Mm.6180
RefSeq NP_085102
MGI ID
MGI Symbol Klrb1b
OMIM
CCDS CCDS39655
HPRD
IMGT
EMBL AF324825 AF324826 AF338321 AF338322 AF342896 AF354260 AK030702 AK041228 AK169820 BC055379 BC100580
GenPept AAH55379 AAI00581 AAK08512 AAK08513 AAK26639 AAK39100 AAL37353 AAL37354 BAC27088 BAC30869 BAE41390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca