Version 5.4
Mus musculus Protein: Hdgfrp2
Summary
InnateDB Protein IDBP-191591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdgfrp2
Protein Name hepatoma-derived growth factor, related protein 2
Synonyms HRP-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000002911
InnateDB Gene IDBG-191589 (Hdgfrp2)
Protein Structure
UniProt Annotation
Function Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non- condensed chromatin in the presence of HDGF. {ECO:0000269PubMed:22212508}.
Subcellular Localization Nucleus {ECO:0000269PubMed:22212508}. Note=Isoform 4 displays a punctate pattern and colocalizes with N- terminally processed HDFG.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:22212508}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1194492
InterPro IPR000313 PWWP domain
IPR021567 Lens epithelium-derived growth factor (LEDGF)
PFAM PF00855
PF11467
PRINTS
PIRSF
SMART SM00293
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UMU9
PhosphoSite PhosphoSite-Q3UMU9
TrEMBL
UniProt Splice Variant
Entrez Gene 15193
UniGene Mm.486565
RefSeq NP_032259
MGI ID
MGI Symbol Hdgfrp2
OMIM
CCDS CCDS28894
HPRD
IMGT
EMBL AK143616 AK144669 AK146813 AK146918 BC003741 D63850 FN687734
GenPept AAH03741 BAA22896 BAE25467 BAE25999 BAE27453 BAE27530 CBK52221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca