InnateDB Protein
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IDBP-191653.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plin5
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Protein Name
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perilipin 5
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Synonyms
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2310076L09Rik; AI415325; AW109675; Lsdp5; MLDP; PAT-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000019808
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InnateDB Gene
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IDBG-191651 (Plin5)
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Protein Structure
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Function |
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. {ECO:0000269PubMed:17130488, ECO:0000269PubMed:19064991, ECO:0000269PubMed:21393244, ECO:0000269PubMed:21885430, ECO:0000269PubMed:22532565, ECO:0000269PubMed:22675471, ECO:0000269PubMed:23345411}.
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Subcellular Localization |
Lipid droplet. Cytoplasm. Mitochondrion {ECO:0000250}. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Highly expressed in oxidative tissues, including heart, liver, brown adipose tissue (BAT) and slow-twitch fibers of skeletal muscle. Lower expression in epididymal white adipose tissue and anterior tibialis and quadriceps. Expressed in adrenal glands. Isoform 2 has the highest expression in heart. {ECO:0000269PubMed:16571721, ECO:0000269PubMed:17130488, ECO:0000269PubMed:17234449}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006629
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lipid metabolic process
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GO:0010867
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positive regulation of triglyceride biosynthetic process
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GO:0010884
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positive regulation of lipid storage
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GO:0010890
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positive regulation of sequestering of triglyceride
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GO:0010897
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negative regulation of triglyceride catabolic process
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GO:0019915
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lipid storage
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GO:0031999
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negative regulation of fatty acid beta-oxidation
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GO:0032000
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positive regulation of fatty acid beta-oxidation
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GO:0034389
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lipid particle organization
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GO:0035359
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negative regulation of peroxisome proliferator activated receptor signaling pathway
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GO:0050995
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negative regulation of lipid catabolic process
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GO:0051646
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mitochondrion localization
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GO:0060192
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negative regulation of lipase activity
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GO:0060193
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positive regulation of lipase activity
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GO:2000378
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negative regulation of reactive oxygen species metabolic process
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Cellular Component |
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PDB ID |
MGI:1914218
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InterPro |
IPR004279
Perilipin
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PFAM |
PF03036
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PRINTS |
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PIRSF |
PIRSF036881
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BVZ1
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PhosphoSite |
PhosphoSite-Q8BVZ1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66968
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UniGene |
Mm.254985
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RefSeq |
NP_080150
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MGI ID |
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MGI Symbol |
Plin5
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OMIM |
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CCDS |
CCDS37662
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HPRD |
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IMGT |
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EMBL |
AK075872
AY919875
BC024138
DQ473305
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GenPept |
AAH24138
AAX12443
ABF13218
BAC36019
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