Version 5.4
Mus musculus Protein: Chsy1
Summary
InnateDB Protein IDBP-191661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chsy1
Protein Name chondroitin sulfate synthase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047487
InnateDB Gene IDBG-191659 (Chsy1)
Protein Structure
UniProt Annotation
Function Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
GO:0046872 metal ion binding
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
Biological Process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030279 negative regulation of ossification
GO:0031667 response to nutrient levels
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID MGI:2681120
InterPro IPR003378 Fringe-like
IPR008428 Chondroitin N-acetylgalactosaminyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF02434
PF05679
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZQ11
PhosphoSite PhosphoSite-Q6ZQ11
TrEMBL
UniProt Splice Variant
Entrez Gene 269941
UniGene Mm.333916
RefSeq NP_001074632
MGI ID
MGI Symbol Chsy1
OMIM
CCDS CCDS39978
HPRD
IMGT
EMBL AK129255
GenPept BAC98065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca