InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrk1

Summary

InnateDB Protein

IDBP-191679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrk1

Protein Name

leucine-rich repeat kinase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015277

InnateDB Gene

IDBG-191677 (Lrrk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:Q38SD2}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007264	small GTPase mediated signal transduction
GO:0008150	biological_process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:2142227

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001611 Leucine-rich repeat
IPR001806 Small GTPase superfamily
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003591 Leucine-rich repeat, typical subtype
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011009 Protein kinase-like domain
IPR013684 Mitochondrial Rho-like
IPR017986 WD40-repeat-containing domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM