Version 5.4
Mus musculus Protein: Klrb1f
Summary
InnateDB Protein IDBP-191759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klrb1f
Protein Name killer cell lectin-like receptor subfamily B member 1F
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000032257
InnateDB Gene IDBG-191757 (Klrb1f)
Protein Structure
UniProt Annotation
Function Binds CLEC2I/Clr-g leading to activation of natural killer cells or costimulation of IL-2 production and proliferation of T-cells in response to antigen stimulation. May contribute to the formation of the immunological synapse between T-cells and antigen-presenting dendritic cells. {ECO:0000269PubMed:12858173, ECO:0000269PubMed:15963483, ECO:0000269PubMed:16143319}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in dendritic cells. Detectable in natural killer cells. {ECO:0000269PubMed:15963483}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2442965
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VD98
PhosphoSite PhosphoSite-
TrEMBL Q3KNP3
UniProt Splice Variant
Entrez Gene 232408
UniGene Mm.259262
RefSeq NP_694734
MGI ID
MGI Symbol Klrb1f
OMIM
CCDS CCDS20579
HPRD
IMGT
EMBL AF320600 AK041601 AK154278 AK170023 AY029597 BC107177 BC107178 BC127141 BC127142 CH466523 DQ143105 DQ237931 JX026279
GenPept AAI07178 AAI07179 AAI27142 AAI27143 AAK38158 AAL37201 ABA43356 ABB72029 AFK08673 BAC31001 BAE32484 BAE41516 EDK99910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca