InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clec2d

Summary

InnateDB Protein

IDBP-191825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clec2d

Protein Name

C-type lectin domain family 2, member d

Synonyms

Clr-b; Clrb; Ocil;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032260

InnateDB Gene

IDBG-191823 (Clec2d)

Protein Structure

UniProt Annotation

Function

Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Binds high molecular weight sulfated glycosaminoglycans. {ECO:0000269PubMed:11278931, ECO:0000269PubMed:12374791, ECO:0000269PubMed:14990792, ECO:0000269PubMed:16751398}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14990792}; Single-pass type II membrane protein {ECO:0000269PubMed:14990792}. Cell surface {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in fetal heart, brain, lung, chondrocytes, perichondrium and osteoblasts, and in adult splenocytes, thymocytes, lymph-node cells, osteoblasts, growth plate chondrocytes and skeltal muscle overlying the bone (at protein level). Ubiquitous. Detected in thymus, bone marrow, lung, gut, heart, skeletal muscle, ovary, spleen, ileum, liver and kidney. {ECO:0000269PubMed:11278931, ECO:0000269PubMed:11398965, ECO:0000269PubMed:12374791, ECO:0000269PubMed:14990792, ECO:0000269PubMed:16751398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0046703	natural killer cell lectin-like receptor binding

Biological Process

GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0042270	protection from natural killer cell mediated cytotoxicity
GO:0045671	negative regulation of osteoclast differentiation