InnateDB Protein
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IDBP-191848.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aldh1a3
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Protein Name
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aldehyde dehydrogenase family 1, subfamily A3
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Synonyms
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ALDH6; RALDH3; V1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000015278
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InnateDB Gene
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IDBG-191846 (Aldh1a3)
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Protein Structure
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Function |
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. {ECO:0000269PubMed:10906479, ECO:0000269PubMed:11013254, ECO:0000269PubMed:11025231, ECO:0000269PubMed:11044606}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11013254}.
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Disease Associations |
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Tissue Specificity |
Ventral retina. {ECO:0000269PubMed:10906479, ECO:0000269PubMed:11013254, ECO:0000269PubMed:11025231, ECO:0000269PubMed:11044606}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1861722
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InterPro |
IPR015590
Aldehyde dehydrogenase domain
IPR016161
Aldehyde/histidinol dehydrogenase
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PFAM |
PF00171
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JHW9
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PhosphoSite |
PhosphoSite-Q9JHW9
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TrEMBL |
Q810V9
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UniProt Splice Variant |
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Entrez Gene |
56847
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UniGene |
Mm.140988
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RefSeq |
NP_444310
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MGI ID |
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MGI Symbol |
Aldh1a3
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OMIM |
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CCDS |
CCDS21345
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HPRD |
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IMGT |
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EMBL |
AF152359
AF246711
AF253409
AF280404
AK147006
BC048941
BC058277
CH466543
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GenPept |
AAF67736
AAF86980
AAG33935
AAG38488
AAH48941
AAH58277
BAE27602
EDL07219
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