InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fem1a

Summary

InnateDB Protein

IDBP-191899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fem1a

Protein Name

feminization 1 homolog a (C. elegans)

Synonyms

AW611390; Fem1aa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057996

InnateDB Gene

IDBG-191897 (Fem1a)

Protein Structure

UniProt Annotation

Function

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in adult heart and skeletal muscle. {ECO:0000269PubMed:9828124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043407	negative regulation of MAP kinase activity
GO:0050728	negative regulation of inflammatory response
GO:0051438	regulation of ubiquitin-protein ligase activity