InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ticam1

Summary

InnateDB Protein

IDBP-191914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ticam1

Protein Name

toll-like receptor adaptor molecule 1

Synonyms

AW046014; AW547018; TICAM-1; TRIF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055104

InnateDB Gene

IDBG-191912 (Ticam1)

Protein Structure

UniProt Annotation

Function

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269PubMed:12855817, ECO:0000269PubMed:16002681}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0030890	positive regulation of B cell proliferation
GO:0031398	positive regulation of protein ubiquitination
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032092	positive regulation of protein binding
GO:0032481	positive regulation of type I interferon production
GO:0032496	response to lipopolysaccharide
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032816	positive regulation of natural killer cell activation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0043496	regulation of protein homodimerization activity
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050871	positive regulation of B cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0097190	apoptotic signaling pathway