Version 5.4
Mus musculus Protein: Dstyk
Summary
InnateDB Protein IDBP-191934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dstyk
Protein Name dual serine/threonine and tyrosine protein kinase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035358
InnateDB Gene IDBG-191932 (Dstyk)
Protein Structure
UniProt Annotation
Function May induce both caspase-dependent apoptosis and caspase- independent cell death. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, heart, skeletal muscle, kidney and lung (at protein level). Widely expressed. Highly expressed in many brain regions, including in cerebellum, olfactory, hippocampus and cerebral cortex. {ECO:0000269PubMed:17123648}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID MGI:1925064
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6XUX1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 213452
UniGene Mm.401532
RefSeq NP_766104
MGI ID
MGI Symbol Dstyk
OMIM
CCDS CCDS15285
HPRD
IMGT
EMBL AK020880 AK043199 AK050542 AK145449 AY208852 AY429676 BC089380
GenPept AAH89380 AAP42420 AAS55392 BAB32238 BAC31487 BAC34316 BAE26444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca