InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Creb3l1

Summary

InnateDB Protein

IDBP-191937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Creb3l1

Protein Name

cAMP responsive element binding protein 3-like 1

Synonyms

Oasis;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028663

InnateDB Gene

IDBG-191935 (Creb3l1)

Protein Structure

UniProt Annotation

Function

Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. {ECO:0000269PubMed:12480185, ECO:0000269PubMed:15665855}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15665855}; Single-pass type II membrane protein {ECO:0000269PubMed:15665855}.Processed cyclic AMP-responsive element- binding protein 3-like protein 1: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Disease Associations

Tissue Specificity

Expressed at relatively low levels in lung and kidney. Weakly expressed in brain and spleen. {ECO:0000269PubMed:10350641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0030500	regulation of bone mineralization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1347062

InterPro

IPR001630 cAMP response element binding (CREB) protein
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF00170
PF07716

PRINTS

PR00041

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt