InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nup107

Summary

InnateDB Protein

IDBP-191942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nup107

Protein Name

nucleoporin 107

Synonyms

AW541137; C76801;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063590

InnateDB Gene

IDBG-191940 (Nup107)

Protein Structure

UniProt Annotation

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore

Biological Process

GO:0006406	mRNA export from nucleus
GO:0006810	transport
GO:0015031	protein transport
GO:0051292	nuclear pore complex assembly

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005813	centrosome
GO:0016020	membrane
GO:0031080	nuclear pore outer ring
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery