InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Olr1

Summary

InnateDB Protein

IDBP-192021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Olr1

Protein Name

oxidized low density lipoprotein (lectin-like) receptor 1

Synonyms

LOX-1; Scare1; SR-EI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032265

InnateDB Gene

IDBG-192019 (Olr1)

Protein Structure

UniProt Annotation

Function

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Secreted {ECO:0000250}. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0002376	immune system process
GO:0006898	receptor-mediated endocytosis
GO:0006954	inflammatory response
GO:0007159	leukocyte cell-cell adhesion
GO:0008219	cell death
GO:0042157	lipoprotein metabolic process
GO:0042542	response to hydrogen peroxide

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0019897	extrinsic component of plasma membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome